Endocrine Abstracts

Purpose: The purpose of this study was to evaluate the relation polycystic ovarian syndome (PCOS) and the thiol/disulfide balance, used as a marker of oxidative stress, by measuring that exchange using a novel technique.Material/methods: Fourty nine subjects diagnosed with PCOS and 44 healthy were included in the study. Thiol/disulfide homeostasis concentrations were measured by a newly developed method. After native thiol, total thiol and disulfide leve...

Introduction: Phaeochromocytomas (PHEO) are diagnosed with classic findings and symptoms but biochemical confirmation must be made. Either urinary or plasma chatecholamines and metanephrines can be used for biochemical evaluation. Normal values rule out the diagnosis, whereas fourfold increase above the upper limit of normal confirm the diagnosis. But value of borderline or less than fourfold elevations in the diagnosis is not clear. We aimed to determine the urinary fractiona...

Objective: To investigate dynamic thiol/disulphide homeostasis in autoimmune subclinical hypothyroidism.Materials and methods: 48 patients with newly diagnosed subclinical hypothyroidism due to Hashimoto’s thyroiditis and not yet on any treatment and 48 healthy subjects without any known disease were enrolled. Thiol/disulfide homeostasis (native thiol(-SH)–disulphide(-S-S-) exchanges) was measured in both groups with new method developed by Ere...

Background: Diabetic retinopathy (DR) is the leading cause of blindness in the world. Retinopathy and nephropathy can still progress in diabetics despite optimal metabolic control. The aim of the present study was to determine whether different degrees of DR (proliferative or non-proliferative) were associated with abnormally modulated hemostatic parameters in patients with type 1 DM.Method: 52 type 1 diabetic patients and 40 healthy controls were enroll...

AimEuthyroid Sick Syndrome (ESS) is a thyroid disease appeared in critical and noncritical illnesses. ESS can be seen in patients with end stage renal disease (ESRD). In this study, we aimed to evaluate the frequency of ESS before and after renal transplantation in patients with ESRD, and its association with oxidative stress by evaluating thiol-disulphide levels.Material and MethodIn this study, free triiodo...

Aim: In this study we aimed to evaluate the oxidative stress via evaluating changes in dynamic thiol-disulphide status in euthyroid patients with Hashimoto’s thyroiditis (HT).Methods: Fifty euthyroid patients with HT and 50 healthy individuals were enrolled in this study. Thyroid function tests (free triiodothyronine (fT3), free thyroxine (fT4), thyrotropin (TSH)), acute phase reactants (C-reactive protein (CRP), high sensitive CRP (hs-CRP)) and thi...

Objective: Thiols are organic compounds that contain sulphydryl group (-SH) and have important role in preventing oxidative stress especially in cells. The aim of our study is to investigate the relationship between hypothyroidism due to HT and the thiol disulfide homeostasis, the effect of treatment on this homeostasis and to demonstrate the utility of thiol/disulphide homestasis as a marker for assessing the damage to functional group of proteins and the oxidative balance in...

Background: Thiol/disulfide homeostasis plays an important role in antioxidative defense mechanism, detoxification, signal transport, management of enzyme activity and trascription factors, and apoptosis. When thiol/disulphide homeostasis breaks down, these important cellular functions get deranged. Pathologies secondary to oxidative stress are seen in organeles in which this homeostasis is deranged. The aim of the study was to investigate dynamic thiol/disulfide homeostasis i...

Objective: The aim of our study was to determine whether there is a relationship between oxidative stress parameters and subacute thyroiditis.Material and methods: The study included 55 subacute thyroiditis patients and 30 healthy volunteers. Total antioxidant status (TAS), total oxidant status (TOS), paraoxonase (PON) and thiol/disulfide homeostasis parameters were measured by a novel and automated assay in the patient and control groups.<p class="a...

BackgroundUltrasonography and fine needle aspiration biopsy are frequently used in the diagnosis of thyroid cancer. However, supportive data might be required in case of diagnostic difficulty. In this study, we investigated whether there is a relationship between thiol/disulfide homeostasis and cytological and histopathological diagnosis of thyroid nodules.Materials and methodsA total of 119 participants were...